Recombinant dengue type 2 viruses with altered e protein domain III epitopes are efficiently neutralized by human immune sera.

نویسندگان

  • Wahala M P B Wahala
  • Claire Huang
  • Siritorn Butrapet
  • Laura J White
  • Aravinda M de Silva
چکیده

Humans develop polyclonal, serotype-specific neutralizing antibody responses after dengue virus (DENV) infection. Many mouse antibodies that neutralize DENV bind to the lateral ridge or A strand epitopes on domain III of the viral envelope (EDIII) protein. It has been assumed that these epitopes are also the main target of human neutralizing antibodies. Using recombinant dengue serotype 2 viruses with altered EDIII epitopes, we demonstrate that EDIII epitopes are not the main target of human neutralizing antibody.

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عنوان ژورنال:
  • Journal of virology

دوره 86 7  شماره 

صفحات  -

تاریخ انتشار 2012